Childhood Origins of ASThma (COAST)
The Childhood Origins of ASThma (COAST) study was funded by the National Heart Lung and Blood Institute (National Institutes of Health, Bethesda, MD) in September 1998 and launched in November of that same year. A cohort of children (n = 287) at increased risk of developing asthma (at least one parent with allergies and/or asthma) were enrolled at birth.
Ronald Gangnon
Professor of Biostatistics
Publications
Rhinoviruses A and C Elicit Long-Lasting Antibody Responses with Limited Cross-Neutralization
Background: Rhinoviruses (RVs) can cause severe wheezing illnesses in young children and patients with asthma. Vaccine development has …
Enhanced Neutralizing Antibody Responses to Rhinovirus C and Age-Dependent Patterns of Infection
Rationale: Rhinovirus C (RV-C) can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe …
Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma development
BACKGROUND:
Biomarkers, preferably noninvasive, that predict asthma inception in children are lacking. OBJECTIVE:
Little is known about …
Genetic associations with viral respiratory illnesses and asthma control in children
BACKGROUND:
Viral respiratory infections can cause acute wheezing illnesses in children and exacerbations of asthma. OBJECTIVE:
We …
Sex-related differences in pulmonary physiologic outcome measures in a high-risk birth cohort
BACKGROUND:
Sex influences the risk of wheezing illnesses and the prevalence of asthma throughout childhood. OBJECTIVE:
To better …
Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations
BACKGROUND:
Detection of either viral or bacterial pathogens is associated with wheezing in children; however, the influence of both …
Evaluation of the modified asthma predictive index in high-risk preschool children
BACKGROUND:
Prediction of subsequent school-age asthma during the preschool years has proven challenging. OBJECTIVE:
To confirm in a …
Human rhinovirus species and season of infection determine illness severity
RATIONALE:
Human rhinoviruses (HRVs) consist of approximately 160 types that cause a wide range of clinical outcomes, including …
Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children
BACKGROUND:
Children with allergic asthma have more frequent and severe human rhinovirus (HRV)-induced wheezing and asthma …
Protection from asthma in a high-risk birth cohort by attenuated P2X(7) function
BACKGROUND:
Viral illnesses are important factors in both asthma inception and exacerbations, and allergic sensitization in early life …
Increased H1N1 infection rate in children with asthma
RATIONALE:
The 2009 H1N1 flu appeared to cause more severe cold symptoms during the 2009-2010 flu season. OBJECTIVES:
We evaluated H1N1 …
Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life
RATIONALE:
Aeroallergen sensitization and virus-induced wheezing are risk factors for asthma development during early childhood, but …
Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma
BACKGROUND:
Preschool rhinovirus (RV) wheezing illnesses predict an increased risk of childhood asthma; however, it is not clear how …
IFNG genotype and sex interact to influence the risk of childhood asthma
BACKGROUND:
Asthma is a complex disease characterized by sex-specific differences in incidence, prevalence, and severity, but little is …
Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children
BACKGROUND:
Factors affecting fractional exhaled nitric oxide (FeNO) in early childhood are incompletely understood. OBJECTIVE:
To …
Effects of dog ownership in early childhood on immune development and atopic diseases
BACKGROUND:
Exposure to pets in childhood has been associated with a reduced risk of wheezing and atopy. OBJECTIVE:
Our objective was …
Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children
RATIONALE:
Virus-induced wheezing episodes in infancy often precede the development of asthma. Whether infections with specific viral …
The influence of processing factors and non-atopy-related maternal and neonate characteristics on yield and cytokine responses of cord blood mononuclear cells
RATIONALE:
Several studies have evaluated the associations between cord blood cellular responses and atopic diseases in children, but …
Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life
BACKGROUND:
Viral infections are the major cause of acute wheezing illnesses in childhood. Variations in immunologic responses at birth …
Viral infections, cytokine dysregulation and the origins of childhood asthma and allergic diseases
BACKGROUND:
The origins of asthma and allergic disease begin in early life for many individuals. It is vital to understand the factors …
Rhinovirus illnesses during infancy predict subsequent childhood wheezing
BACKGROUND:
The contribution of viral respiratory infections during infancy to the development of subsequent wheezing and/or allergic …
Gene-environment interaction effects on the development of immune responses in the 1st year of life
Asthma is a common disease that results from both genetic and environmental risk factors. Children attending day care in the 1st year …
Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life
Daycare attendance and siblings are associated with viral-induced wheezing in children. Preexisting immunologic factors may influence …
Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy
BACKGROUND:
Asthma is a chronic respiratory disease that often originates in early childhood. Although candidate gene studies have …
Effects of dog ownership and genotype on immune development and atopy in infancy
BACKGROUND:
Exposure to furred pets might confer protection against the development of allergic sensitization through a mechanism that …
Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life
BACKGROUND:
Allergic diseases have been linked to abnormal patterns of immune development, and this has stimulated efforts to define …
